While in Paris on business, Harvard symbologist Robert Langdon receives an urgent late-night phone call: the elderly curator of the Louvre has been murdered inside the museum. Near the body, police have found a baffling cipher. Solving the enigmatic riddle, Langdon is stunned to discover it leads to a trail of clues hidden in the works of da Vinci…clues visible for all to see…and yet ingeniously disguised by the painter.

Langdon joins forces with a gifted French cryptologist, Sophie Neveu, and learns the late curator was involved in the Priory of Sion-an actual secret society whose members included Sir Isaac Newton, Botticelli, Victor Hugo, and da Vinci, among others. The Louvre curator has sacrificed his life to protect the Priory's most sacred trust: the location of a vastly important religious relic, hidden for centuries.

In a breathless race through Paris, London, and beyond, Langdon and Neveu match wits with a faceless powerbroker who appears to work for Opus Dei-a clandestine, Vatican-sanctioned Catholic sect believed to have long plotted to seize the Priory's secret. Unless Langdon and Neveu can decipher the labyrinthine puzzle in time, the Priory's secret-and a stunning historical truth-will be lost forever.